Twenty-four hours after the propranolol or saline treatment (i.p.), rats were subjected to the reinstatement test induced by drug cues. The test condition was identical to that of heroin self-administration training, with the exception that active nosepokes led to contingent presentations of the tone-light cue that had been previously paired with heroin and were not reinforced with heroin. The reinstatement test lasted 1 h.
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