Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

IGAP summary statistics

IR Itziar de Rojas
SM Sonia Moreno-Grau
NT Niccolo Tesi
BG Benjamin Grenier-Boley
VA Victor Andrade
IJ Iris E. Jansen
NP Nancy L. Pedersen
NS Najada Stringa
AZ Anna Zettergren
IH Isabel Hernández
LM Laura Montrreal
CA Carmen Antúnez
AA Anna Antonell
RT Rick M. Tankard
JB Joshua C. Bis
RS Rebecca Sims
CB Céline Bellenguez
IQ Inés Quintela
AG Antonio González-Perez
MC Miguel Calero
EF Emilio Franco-Macías
JM Juan Macías
RB Rafael Blesa
LC Laura Cervera-Carles
MM Manuel Menéndez-González
AF Ana Frank-García
JR Jose Luís Royo
FM Fermin Moreno
RV Raquel Huerto Vilas
MB Miquel Baquero
MD Mónica Diez-Fairen
CL Carmen Lage
SG Sebastián García-Madrona
PG Pablo García-González
EA Emilio Alarcón-Martín
SV Sergi Valero
OS Oscar Sotolongo-Grau
AU Abbe Ullgren
AN Adam C. Naj
AL Afina W. Lemstra
AB Alba Benaque
AP Alba Pérez-Cordón
AB Alberto Benussi
AR Alberto Rábano
AP Alessandro Padovani
AS Alessio Squassina
AM Alexandre de Mendonça
AP Alfonso Arias Pastor
AK Almar A. L. Kok
AM Alun Meggy
request Request a Protocol
ask Ask a question
Favorite

The GWAS summary results from the IGAP were downloaded from the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS, https://www.niagads.org/)20. Details on data generation and analyses by the IGAP have been previously described20. In brief, the IGAP is a large study based upon genome-wide association using individuals of European ancestry. Stage 1 of the IGAP comprises 21,982 AD cases and 41,944 cognitively normal controls from four consortia: the Alzheimer Disease Genetics Consortium (ADGC), the European Alzheimer’s Disease Initiative (EADI), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, and the Genetic and Environmental Risk in AD/Defining Genetic, Polygenic, and Environmental Risk for Alzheimer’s Disease (GERAD/PERADES) Consortium. Summary statistics are available for 11,480,632 variants, both genotyped and imputed (1000 Genomes phase 1, v3). In Stage 2, 11,632 SNPs were genotyped in an independent set of 8362 AD cases and 10,483 controls.

Copyright and License information: The Author(s) ©2021
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A