The Kolmogorov-Smirnoff test was used to check the normality of the data. S100B levels showed non-normal distribution, thus nonparametric methods were used. The U-Mann–Whitney test, Kruskal–Wallis Anova, and paired Wilcoxon signed rank test were applied in the analyses. Linear regression was used in S100B x symptoms severity, and in gender analyses. Spearman’s rank correlation between S100B baseline levels and clinical variables was performed. The significance level after Bonferroni correction for multiple testing was set at p < 0.007. The statistical analyses were performed using the R project23 and Statistica v13 software24.
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