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2.5. Statistical analysis

TH Takehiro Hasegawa
AN Atsushi Nakagawa
KS Kohjin Suzuki
KY Kazuto Yamashita
SY Saya Yamashita
NI Niina Iwanaga
ET Eiya Tamada
KN Kenta Noda
KT Keisuke Tomii
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Owing to the non-normal distribution of data, data were described in terms of medians and interquartile ranges (IQR). Two-tailed P values < 0.05 were considered significant. Fisher’s exact test, the Steel–Dwass test, and Mann–Whitney U test were applied using R (r-project) [13]. The Wilcoxon test was used to analyse the biomarker changes accompanying disease progression. Unsupervised hierarchical cluster analysis was performed using Cluster 3.0 (University of Tokyo Human Genome Centre). The cluster analysis was performed using a complete linkage based on Euclidean distance.

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