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Interpretation of Fractional Inhibitory Concentration Index (FICI)

WF Wenli Feng
JY Jing Yang
YM Yan Ma
ZX Zhiqin Xi
YJ Ying Ji
QR Qiao Ren
HN Huan Ning
SW Shaoyan Wang
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The fractional inhibitory concentration index (FICI) was used to determine the interaction of the two drugs in combination, and the results were interpreted according to the methods of Tamura et al22 and Odds et al.23 The following formula was used for the calculation: FICI= (MICA in combination/MICA alone) + (MICB in combination/MICB alone). The effects of the antifungal drug combinations were classified according to the following criteria: (1) FICI ≤ 0.5, synergistic effects; (2) 0.5 < FICI ≤ 1, additive effects; (3) 1 < FICI < 4, no interactions; (4) FICI ≥ 4.0, antagonistic effects.

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