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Corticotropin-releasing hormone (CRH) loading test
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One ampule of corticorelin (human, 100 μg, Nipro ES Pharma Co., Ltd., Osaka, Japan) was intravenously injected and ACTH and cortisol levels were measured at baseline, and at 30, 60, 90, and 120 min. The plasma ACTH level at peak after loading corticorelin was increased to 2–3-fold higher than baseline and also above 35 pg/mL in patients with normal pituitary function (normal response). A cortisol level above 18 μg/dL at peak after loading coticorelin revealed that the patient had a normal adrenal function in addition to a normal pituitary function.
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