2.9. Covariate Distribution of True and False Positive Cases

Figure 3 shows a density plot of age at collection and birth weight of the true and false positive cases in the Validation set listed in Table 4. It clearly shows the disproportionate aggregation of false positive cases when the age at collection in newborns close to 1 h, 1 week, or <2500 g of birth weight.

Covariate distribution of the Validation set. Legend: Covariate density plot of false positive (N = 10,556) and true positive (N = 915) cases from the Validation set. (Panel A): False positives; (Panel B): True positives. Kernel density estimation (KDE) function [31] was used to calculate probability density function of each class, and it was displayed using a contour plot. The unit values are the same as the input unit values. The scale is log10 on the Y axis and linear on the X axis of the plot. Color gradients are relative to case count.