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Synthesis and characterization of piceatannol phosphate

MX Minjun Xu
KH Kaili Hu
YL Yipu Liu
YH Yukun Huang
SL Shanshan Liu
YC Yu Chen
DW Dayuan Wang
SZ Songlei Zhou
QZ Qian Zhang
NM Ni Mei
HL Huiping Lu
FL Fengan Li
XG Xiaoling Gao
JC Jun Chen
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Piceatannol phosphate (PP) was synthesized with some modification. Briefly, 0.8 mmol piceatannol, DMAP, and Et3N were added at THF. Then, 23 mmol ClP(O)(OEt)2 was added to a dropwise ice water bath at 70 °C for 24 h. Next, the mixture was purified using column chromatography to obtain the ethyl-protected PP, which was characterized by 1H NMR, 13C HMR, and 31P NMR.

Then, the 0.065 mmol ethyl-protected PP and trimethylsilyl bromide were mixed in dichloromethane. After 2 days of stirring, methanol was added and stirred for 1 h. Then, we use high preparative performance liquid chromatography to obtain PP, which was characterized by 1H NMR, 13C HMR, and 31P NMR.

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