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Inverted screen test

ST Sudheer K. Tungtur
HW Heather M. Wilkins
RR Robert S. Rogers
YB Yomna Badawi
JS Jessica M. Sage
AA Abdulbaki Agbas
OJ Omar Jawdat
RB Richard J. Barohn
RS Russell H. Swerdlow
HN Hiroshi Nishimune
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Evaluation of muscle strength: For SOD1G93A mice, muscle strength was evaluated using an inverted screen test 43,44. In brief, the mouse was placed in the center of stainless-steel wire mesh. Then, the screen was smoothly inverted and held ∼40 cm above a soft surface. The time until the mouse fell from the wire was measured. If the mouse stayed on the metal mesh for 120 s or longer, the mouse was returned to the home cage. Mice were provided one-minute intervals between the three consecutive trials. The inverted screen test was performed by personnel blinded to the treatment group and randomized animals.

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