A systematic literature search was conducted with the assistance of a librarian in PubMed, Cochrane Library, CINAHL Plus, and Web of Science databases to identify all relevant studies on the management of postoperative pain in LMIC. A comprehensive search strategy was developed using a combination of MeSH term “pain, postoperative” with keywords “postoperative pain”, “postoperative pain management”, “postoperative pain relief”, “postoperative analgesia”, “postoperative surgical pain” with suitable Boolean searching [9, 10]. We used the list of LMICs generated by the World Bank which includes 47 countries with a gross national income (GNI) per capita between $1026 and $3995. We included all 47 countries as per the list in our Boolean search [11].
A filter was applied for limiting the search to only human studies published from January 2008 to – June 2019. A total of 2885 studies were extracted and after removing duplicates, 2196 studies were selected. A total of 1450 randomized control trials (RCTs) were found out of 2196 in the pre-specified list of 47 countries.
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