Small-molecule Lats inhibitor

NK Nathaniel Kastan
KG Ksenia Gnedeva
TA Theresa Alisch
AP Aleksandra A. Petelski
DH David J. Huggins
JC Jeanne Chiaravalli
AA Alla Aharanov
AS Avraham Shakked
ET Eldad Tzahor
AN Aaron Nagiel
NS Neil Segil
AH A. J. Hudspeth
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The compound N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide (CAS number 1424635-83-5), of relative molecular mass 334.4 Da and herein termed TRULI, was originally obtained from Enamine LLC (Z730688380, Monmouth Junction, NJ). We confirmed the structure of the compound by additional synthesis and by performing nuclear magnetic resonance (NMR; Supplementary Fig. 7) and liquid chromatography–mass spectrometry (LC–MS; Supplementary Fig. 8), and used the 99 % pure material in experiments.

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