GSRS is a validated GI questionnaire that utilises a 7-level Likert scale (1–7), based on the intensity and frequency of GI symptoms experienced during the previous seven days. A higher score represents the main symptoms complained about by the patients. The 7-level scores were then merged to obtain a four-level score of intensity/frequency: absent, mild, moderate, and severe. The combination scores among the GSRS items identified four clusters: (a) “Abdominal pain syndrome” collects abdominal pain, gastric hunger pain, and nausea scores; (b) “Dyspepsia syndrome” collects halitosis, heartburn, and regurgitation scores; (c) “Indigestion syndrome” collects abdominal distension, borborygmi, burping, and flatulence scores; (d) “Diarrhoea syndrome” collects increased frequency of evacuation, loose stools, and urgent need to defecate scores [36].
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