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PFS ratio per rs671 group

AM Akiko Matsumoto
CN Chiho Nakashima
SK Shinya Kimura
ES Eizaburo Sueoka
NA Naoko Aragane
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The PFS ratio was determined by rs671 groups because the effects of covariates on ICI treatment are likely to differ between rs671 groups based on biological assumptions. For example, chemotherapy before ICI for patients with rs671(+) may cause more T cell immunity loss because their basic T cell count is lower than that of patients with rs671(−) [25]. If grouped by rs671, the proportional hazard assumption for the total observation period is maintained between sub-groups (Fig. 2). Therefore, the HR was estimated using a Cox proportional hazard model (PHREG procedure in SAS 9.4).

Progression-free survival after the initiation of immune checkpoint inhibitor therapy by ALDH2 rs671 polymorphism. Kaplan–Meier plots were shown for patients with thoracic malignancies. ICI; immune checkpoint inhibitor, Rs671(−); ALDH2*1/*1, rs671(+); ALDH2*1/*2 or ALDH2*2/*2. p, p value for Gahan–Breslow–Wilcoxon test

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