Beta-diversity mediation analysis for microbiome

SM Sofia M. Murga-Garrido
QH Qilin Hong
TC Tzu-Wen L. Cross
EH Evan R. Hutchison
JH Jessica Han
ST Sydney P. Thomas
EV Eugenio I. Vivas
JD John Denu
DC Danilo G. Ceschin
ZT Zheng-Zheng Tang
FR Federico E. Rey
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For beta-diversity distance matrices, we performed the distance-based mediation test by using the MedTest package in R language [108]. The Jaccard and unweighted UniFrac distance matrices were calculated based on the rarefied genus-level abundance matrix (rarefied to the minimum sequence depth) to reduce potential sequence depth-dependent bias.

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