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In our preliminary study, the change of subjective symptoms in the treatment group was 7.21 ± 4.36 and 4.35 ± 3.15 in the control group. Taking α as 0.05, β as 0.2 with a 2-sided test, and considering a dropout of 20%, 72 patients will be needed totally.
Copyright and License information: ©2021 the Author(s). Published by Wolters Kluwer Health, Inc.
This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
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