Statistical Analysis

Patient and treatment baseline characteristics were collected and analysed. Goal importance was calculated both as the mean PNQ score per item and the percentage of patients rating a goal ‘quite’ or ‘very’ important (=PNQ score 3 or 4). In case of missing PNQ data, importance scores were calculated over the available data. Patient needs were analysed as per biologic, PNQ subscale, gender, age group (< 50 years vs. ≥ 50 years), and biologic treatment history. Additionally, anonymous PNQ data on patients who denied dose reduction were compared to the PNQ data of our study population. Data were analysed using descriptive statistics and standard parameters. In comparing continuous outcomes, independent T-tests were performed for parametric variables and Mann–Whitney U tests were performed for non-parametric variables. The threshold of statistical significance was set at p < 0.05. All statistical analyses were performed using SPSS (Version 25.0, IBM Corp., Armonk, NY, USA).