2.1. Cudrania tricuspidata (CT) Extract Preparation

The leaves of CT collected in Sinan-gun, Jeollanam-do, were naturally dried and applied. The dried CT leaves were extracted with hot water at 90–110 °C for 4 h at a ratio of 1:10 (w/v) to water, cooled to 50 °C, and filtered to remove impurities. The filtered CT extract was concentrated under vacuum pressure at 50–60 °C so that the solid content was 10% to 15% or more. After concentration, dextrin in the same amount relative to the solid content was added (50:50). It was sterilized at 95 °C for 1 h, stirred, and use a spray dryer to dry it under conditions of inlet temperature of 190 °C, an outlet temperature of 95 °C, and a sample supply rate of 12 mL/min.