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5/6 nephrectomy model of rats and experimental groups

YW Yaqiong Wang
TZ Ting Zhang
XC Xuesen Cao
JZ Jianzhou Zou
XD Xiaoqiang Ding
BS Bo Shen
WL Wenlv Lv
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The rats were anaesthetized with isoflurane and subjected to 5/6NT produced by removal of the right kidney. After recovery for 2 weeks, the left kidney was exposed. Animals were randomly distributed and performed with sham surgery (n = 6). The rats were performed with 5/6NT and divided into four groups: no treatment (5/6NT, n = 8), COX2 inhibitors (5/6NT + COX2 in, n = 10), EP2 inhibitors (5/6NT + EP2 in, n = 10), or EP4 inhibitors (5/6NT + EP4 in, n = 10). Finally, all the animals were killed, and heart tissues were harvested for analyses.

Copyright and License information:  ©2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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