Cancer Cell Line Encyclopedia (CCLE)

CCLE (https://portals.broadinstitute.org/ccle) is a free online database, which compiles chromosomal copy number, large-scale parallel sequencing, and gene expression data of human cancer cell lines (23). In this database, there are about one thousand cell lines data for genomic analysis and visualization. We verified the expression of CDCA gene family in HCC cell lines using datasets downloaded from the CCLE database. Differences in transcriptional expression were compared with Student’s t-test using GraphPad Prism 9, and P<0.01 was deemed to be statistically significant.