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Preclinical xenograft experiments to assess efficacy and expansion of CAR‐T cells
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NOD scid gamma mice subcutaneously inoculated with BCMA + RPMI‐8226 tumors were randomized (at 151 mm3 tumor volume) for treatment with vehicle control or ~ 5 million bb2121 CAR‐T cells/mouse. Tumor volumes were measured twice a week, and CD3+ CAR+ T cells were measured (using flow cytometry) to assess PK in blood. 11
Copyright and License information: ©2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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