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The Clusterprofiler package23 in R used protein-protein interaction modules to enrich for pathways of the Kyoto Encyclopedia of Genes and Genomes (KEGG) (p cut-off = 0.01, q cutoff = 0.01). Subsequently, we extracted HBV- and HCC-associated signaling pathways and considered these to be molecular bridges between the two diseases at the functional and pathway levels. To further evaluate the potential diagnostic value of bridge genes for HBV-related HCC, receiver operating characteristic curve (ROC) analysis was performed using the pROC routine24 in R.
Copyright and License information: ©2021 Nong et al.
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