DNA was extracted using the QIAamp DNA Blood Mini Kit (QIAGEN, Germany). Genotyping was performed by StepOnePlus Real-Time PCR System and a TaqMan SNP Genotyping Assay (Applied Biosystems, USA). Linkage disequilibrium was investigated using LDmatrix (National Cancer Institute, https://ldlink.nci.nih.gov/?tab=ldmatrix, accessed on 1 April 2021).
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