The Ingenuity Pathway Analysis (IPA) software was used for pathway enrichment and signaling network analysis in this work. The significantly up-regulated gene expression profile (with fold-change and P-value) based on DEG analysis was employed for the IPA software as the input gene list. Then the two functional models (1, Canonical Pathways, and 2, Signaling Network Analysis) of IPA software were run with default parameters.
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