Gene Ontology Analysis

To understand the biological consequences of chemical exposure, we performed GO term enrichment using GeneGo MetaCore version-19.3 build-69800 from Clarivate Analytics, as described in Garcia et al. (2018). For gene expression data, we imported BRM-generated human gene symbols and their fold changes into MetaCore and performed GO process analysis. For miR data, we sought to assess the biological processes impacted by target genes of miR. Therefore, for each FRC, we imported the TFmiR-generated target gene list (here using both experimentally validated and computationally predicted data) for gene-miR interactions and performed GO process analysis. GO terms with a false discovery rate (FDR) adjusted p ≤ 0.05 were considered significant and data was represented as heatmaps (GraphPad Prism 9, San Diego, CA, United States). All GO outputs are included within Supplementary Table 3.