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Class A GPCR phylogenetic tree construction

NK Nathan H. Kipniss
PD P. C. Dave P. Dingal
TA Timothy R. Abbott
YG Yuchen Gao
HW Haifeng Wang
AD Antonia A. Dominguez
LL Louai Labanieh
LQ Lei S. Qi
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The phylogenetic tree in Fig. 4a was constructed using GPCRdb41, 42. Human GPCRs from the Swiss-Prot database were used as reference, without any selection for G protein preference. One GPCR from each family of Class A/Rhodopsin Family GPCRs was used to construct the tree, including those utilized in this study. Full-length sequences of receptors were considered for tree construction. No bootstrapping was performed, and distance calculation utilized the neighbor-joining method, with the regular branch lengths option. The tree was then rendered using T-REX43.

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