Values were showed as mean with standard deviation (SD). Paired samples were compared using Student's paired t-test. One-way ANOVA followed by Friedman's post test or two-way ANOVA followed by the Dunnett multiple comparison procedure was also used to determine significance as appropriate. A two-sided p value less than 0.05 was considered statistically significant. Data were analyzed and plotted using the Graphpad Prism Version 7.0.
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