2.2. Literature search strategy

PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases were searched from their establishment dates to March 4, 2021. The language was limited to Chinese or English, regardless of the region. Studies on ATP2B1 polymorphisms, blood pressure levels, and susceptibility to hypertension were collected. The search terms included any of the following: “ATP2B1,” “Plasma membrane calcium-transporting ATPase 1,” “PMCA,” “PMCA1,” or “plasma membrane Ca²⁺-ATPase 1b” as well as “hypertension,” “HTN,” “blood pressure,” “SBP,” or “DBP.” We systematically summarized the genetic polymorphisms in the ATP2B1 gene related to blood pressure phenotypes that have been reported in the literature and supplemented the relevant literature. Supplementary relevant literature was searched in PubMed's dbSNP database (rs2681472 and rs17249754, the 2 most-studied polymorphisms) (https://www.ncbi.nlm.nih.gov/snp). The present study was conducted according to the Cochrane Collaboration and Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 guidelines for meta-analysis and systematic review.^[30]