Improve Research Reproducibility A Bio-protocol resource
- Home
- Protocols
-
Concise Method
Sample size justification
Request a Protocol
Ask a
question
Favorite
According to Julious [83], a sample size of 12 per group is recommended for feasibility randomized clinical trials. A sample size of 20 per group, allowing for a conservative 20% dropout, would give us N = 16 total per group, which exceeded the threshold for a sufficiently precise estimate of variance in continuous variables to use in future studies. Furthermore, with N = 20 per group and 20% attrition, we were 80% powered to detect medium size effects (f = .25) between groups from baseline to follow-up on continuous variables of interest.
Copyright and License information: The Author(s) ©2021
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Do you have any questions about this protocol?
Post your question to gather feedback from the community. We will also invite the authors of this article to respond.
Post a Question0 Q&A
