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Determination of MMR Status

DD Dandan Dong
HL Huajiang Lei
DL Duanya Liu
HB Hansong Bai
YY Yue Yang
BT Baijie Tang
KL Ke Li
JL Juan Liu
GX Gang Xu
XX Xue Xiao
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MMR status of each sample was determined by IHC of MMR proteins (MLH1, MSH2, MSH6, and PMS2). Nuclear staining of lymphocytes, stromal cells or normal endometrium was used as positive internal controls. Mismatch repair deficiency (MMRd) was defined as complete loss of nuclear staining of any MMR protein in tumor cells with presence of positive internal controls. Tumors showed expression of all four MMR proteins were defined as mismatch repair proficiency (MMRp).

Copyright and License information:  ©2021 Dong, Lei, Liu, Bai, Yang, Tang, Li, Liu, Xu and Xiao
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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