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GB Grischa Bratke
SW Steffen Willwacher
FS Florian Siedek
DM David Maintz
DM Daniela Mählich
KW Kilian Weiss
TH Tilman Hickethier
GB Gert-Peter Brüggemann
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This prospective study was approved by the local institutional review board of the University of Cologne and registered in the German Clinical Trials Registry (DRKS00011152) on the 02/07/2018. Informed consent was obtained from all study participants and all procedures were carried out in accordance with relevant guidelines. Participants and corresponding imaging data were acquired from December 2016 until August 2018. Participants needed to be recreationally active, between 18 and 40 years old and without any known neurological disorder, cardiovascular disease, or sport-related injuries at the time of the study (Fig. 1). Dividing the subjects in terms of running speed was based on the previously described correlation between load intensity and muscle activation19–21. The 10 km/h were chosen in order to obtain two groups as equal as possible.

Flow diagram for study participants with exercise protocol and subgroup analysis.

Copyright and License information: The Author(s) ©2021
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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