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Nuclear hormone receptor was performed by DiscoverX (Fremont, CA) on their NHR-Scan platform of cell-based protein-protein interaction assays. This platform employs a β-gal reporter that activates upon interaction of full-length receptor protein with steroid coactivator receptor peptides. In agonist mode, activity of CL2-57 at 10 µM is compared to maximal activity of published positive control agonists; in antagonist mode, reduction in activity with 10 µM CL2-57 from that observed at EC80 of published agonists is quantified.
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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