GEPIA dataset

GEPIA is an interactive web server for analyzing the RNA sequencing expression data that includes 9,736 tumors and 8,587 normal samples from The Cancer Genome Atlas and the Genotype-Tissue Expression projects, using the output of a standard processing pipeline for RNA sequencing data. GEPIA provides customizable functions such as tumor/normal differential expression analysis, profiling according to cancer types or pathological stages, patient survival analysis, similar gene detection, correlation analysis, and dimensionality reduction analysis. GEPIA dynamically plots expression profiles of a given gene according to user-defined sample selections and methods. The results can be presented in box plots. In addition, GEPIA plots gene expression by pathological stages based on the TCGA clinical annotation. GEPIA performs survival analysis based on gene expression levels. This function allows users to select their custom cancer types for survival analysis. For example, to examine the survival curves of an input gene in glioma, we select both GBM and LGG for the survival analyses. GEPIA uses log-rank test for the hypothesis evaluation. The hazard ratio and the 95% confidence interval information can also be included in the survival plot (32).