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PDX models were maintained as in (23). Briefly, resected human pancreatic tumors were implanted into immunocompromised mice. When tumors reached ∼200 mm3, intraperitoneal injections of saline or Gem (200 mg/kg) were administered once a week for 6 weeks. Tumors were harvested, and embedded in paraffin blocks for analysis.
Copyright and License information: ©2016
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