Protein domain enrichment analysis

For each category of proteins, the InterPro (a resource that provides functional analysis of protein sequences by classifying them into families and predicting the presence of domains and important sites) database was researched, and a two-tailed Fisher’s exact test was employed to test the enrichment of the identified modified protein against all proteins in the species database. Protein domains with a corrected p-value < 0.05 were considered significant.