The expression values (log2(FPKM)) of noncanonical AR target genes (Supplementary Data 1) were converted to Z-scores by Z = (x − μ)/σ47, where x is the raw log2(FPKM), μ is the mean and σ is the standard deviation across all samples of a gene. Finally, the Z-scores were summed across all genes to represent the expression score of noncanonical AR target genes. The RNA-seq and clinic data of metastatic CRPC (SU2C/PCF Dream Team)41, treated with ENZ and ABI, was derived from cBioPortal (http://www.cbioportal.org/)62.
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