KEGG Pathway Enrichment Analysis

Genes usually interact with each other to play roles in certain biological functions. Pathway based analysis helps to further understand genes biological functions. Kyoto Encyclopedia of Genes and Genomes (KEGG) is the major public pathway related database (Kanehisa and Goto, 2000). Pathway enrichment analysis in DEGs comparing with the whole genome background can identify DEGs into significantly enriched metabolic pathways or signaling pathways. The calculated p values were gone through FDR Correction, taking FDR ≤0.05 as a threshold. Pathways meeting this condition were defined as significantly enriched pathways in DEGs.