Construction of protein-protein interaction (PPI) network

MY Mingxue Yu
WX Wenli Xu
YJ Yusheng Jie
JP Jiahui Pang
SH Siqi Huang
JC Jing Cao
JG Jiao Gong
XL Xinhua Li
YC Yutian Chong
ask Ask a question
Favorite

STRING online database (http://string-db.org )[25] was applied to detect core candidate genes. Cytoscape software [26] (Version 3.4.0, http://www.cytoscape.org/) was used to construct a PPI relationship network. In addition, the plugin MCODE in Cytoscape was utilized to identify crucial genes of highly intraconnected nodes (degree cutoff ≥ 2, node score cutoff ≥ 0.2, Kcore ≥ 2, and max depth = 100).

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A