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For antibody titers, geometrical mean values and 95 % confidence intervals (CI) were calculated using the software package R 3.5.0. Data were presented either as individual values, as group mean values ± CI where mean values with non-overlapping CI were treated as rejecting the null hypothesis of no difference, or as group Tukey box-plots drawn in the software KaleidaGraph, version 4.1.0 (Synergy Software). Box plots with non-overlapping maximum and minimum values were treated as rejecting the null hypothesis of no difference.
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