Patients were evaluated three weeks after treatment completion and then every two months with clinical examination and blood tests. A contrast-enhanced multiparametric brain MRI was performed 45 days after RT completion and then every two months. Clinical response was evaluated based on the RECIST criteria in patients with macroscopic residual disease after surgery (24). In case of suspected pseudoprogression, a 6-[18F]-L-fluoro-L-3,4-dihydroxyphenylalanine-PET/CT was performed. In case of progressive disease in the brain, patients were considered for salvage treatment on a case-by-case basis (re-operation, second-line chemotherapy or re-irradiation).
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