Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

Assembling the study cohort

IA Ibrahim Ali
RC Rajkumar Chinnadurai
SI Sara T. Ibrahim
PK Philip A. Kalra
ask Ask a question
Favorite

Patient selection into this study is shown in Fig. 1. All the outpatient eGFR values, performed as part of routine renal care and accessed via the hospital’s electronic patient record, were used to calculate the delta (Δ) eGFR slope for each patient using linear regression. As a minimum, we required at least 4 eGFR values over 2 years follow-up for the ΔeGFR to be ascertained for each patient. Patients with a ΔeGFR≤ − 3 ml/min/1.73m2/yr (ie. losing more than 3ml/min/1.73m2/yr), a threshold associated with worse outcomes [2], were defined as a rapid progressor, and they had to have baseline CKD G3a-4 (eGFR 15 to < 60 ml/min/1.73m2) for study inclusion. To differentiate linear versus non-linear progression, the eGFR-time graphs were visually inspected independently by two clinicians, an approach that has been successfully utilised in previous studies [1, 8], and also quantitively assessed with the coefficient of determination (R2).

Assembling the study cohort. Abbreviations: SKS (Salford Kidney Study)

Copyright and License information: The Author(s) ©2021
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A