A number of studies have sought to establish whether exercise could be regarded as an alternative to antidepressants. A systematic review of studies evaluated the effectiveness of exercise as an adjunctive treatment with antidepressants on depression.94 The encompassed studies showed a strong effectiveness of exercise combined with antidepressants for MDD and TRD. There is evidence supporting the role of aerobic exercises in the treatment of depression, and evidence-based recommendations for prescribing exercises in the treatment of MDD have previously been discussed.95 No trials have described worsening in depressive symptoms associated with exercise.
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