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2.7. Fractional Inhibitory Concentration (FIC) Index Calculation
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The data from the checkerboard assay were used for ΣFIC values calculation, and results were analyzed according to the guidelines published by Odds [38]. Fractional inhibitory concentration index (ΣFIC) was calculated for each combination as follows (Equation (1)):
The interaction of two antimicrobial agents was considered synergistic if the ΣFIC was ≤ 0.5, indifferent when the ΣFIC index value was in the range from 0.5 to 4.0, and antagonistic if the ΣFIC was ≥ 4.0.
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