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In a broad scene to evaluate the trend of impact of afatinib on the survival endpoints, the outcomes of OS, PFS, and adverse events from all included RTCs were summarized and criticized. In addition, outcomes of OS, PFS, and adverse events from either NSCLC or HNCSS RCTs were summarized separately.
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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