Risk of bias in individual studies

WL Wei-Cheng Lee
YS Yi-Shing Shieh
YL Yu-Fang Liao
CL Cho-Hao Lee
CH Chiung Shing Huang
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Four authors (WCL, YFL, CHL, and CSH) evaluated each RCT or controlled clinical trial’s quality according to revised Cochrane risk of bias (RoB 2.0) [36] or risk of bias in non-randomized studies of interventions (ROBINS-I) [37], respectively. The quality assessments in the RoB 2.0 included the bias in the randomization process, deviations from the intended interventions, missing outcome data, measurement of the outcome, selection of the reported result, and overall bias. The quality assessments in the ROBINS-I included the bias in the pre-intervention, at intervention, post-intervention, and overall bias. In addition, the quality of the resultant evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) [38].

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