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All experimental animal protocols were approved by the Animal Care and Use Committee of Hebei Medical University, and all the procedures were conducted according to the recommendations of the Laboratory Animal—Guide for Ethical Review of Animal Welfare (GB/T35892–2018). A total of male Sprague–Dawley rats (n = 284, 230–270 g) were purchased from the Laboratory Animal Centre of Hebei Medical University, Hebei, China.

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