Metascape Analysis

XL Xu-Sheng Liu
YG Yan Gao
CL Chao Liu
XC Xue-Qin Chen
LZ Lu-Meng Zhou
JY Jian-Wei Yang
XK Xue-Yan Kui
ZP Zhi-Jun Pei
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Metascape (www.genemania.org) is a free and well-maintained online bioinformatics database for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis (36). In this study, we used Metascape for functional annotation and pathway enrichment analysis of E2Fs and neighboring genes significantly associated with E2Fs. Only terms with P-value <0.01, minimum count >3, and enrichment factor >1.5 were considered as significant.

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