We implemented our approach through the following steps: (1) select a subset of differential genes by applying a paired t-test process on the expression data in Part one, (2) select another set of candidates gene according to the number of their connections in the FIs network, (3) combine the above-mentioned two sets and reconstruct the FIs network with candidate genes in the collection, (4) integrate the reconstructed FIs network with ILFS to score the genes. The flow diagram of our method is plotted in S1 Fig.
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