Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

Combination index calculations

RP Raghu S. Pandurangi
MT Marco Tomasetti
SV Sekar T. Verapazham
RP Ramasamy Paulmurugan
CM Cynthia Ma
SR Sandeep Rajput
MA Manjushree Anjanappa
HN Harikrishna Nakshatri
request Request a Protocol
ask Ask a question
Favorite

Combination Indices were calculated using CompuSyn software, V. 1.0 (Biosoft, Cambridge, UK). Drug interactions were classified by determining a combination index (CI) recognized as the standard measure of combination effect based on the Chou-Talalay method. The CI values were obtained over a range of fractional cell kill levels (Fa) from 0.05 to 0.95 (5–95% cell kill). Based on the Chou-Talalay method, CI < 1 means synergism, CI = 1 means additivity, and CI > 1 is interpreted as antagonism.

Copyright and License information:  ©2021 Pandurangi et al
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A