Panther Analysis: Gene Ontology Overrepresentation Test

PANTHER online software (pantherdb.org/) was applied to identify the Gene Ontology (GO) Cellular Component categories covered by the repertoires of targeted antigens (described in more detail in e-Methods, links.lww.com/NXI/A385). In the first selection steps, we selected only categories that fulfilled all of the following categories: (1) contain ≥3 targeted proteins; (2) whose number of targeted proteins is ≥5× higher for 1 of the 3 groups compared with the corresponding other 2; and (3) cover ≥4% of the CIDP or ONP repertoires. For the analysis based on the group-specific antigen repertoires, the percentage represents the frequency of targeted proteins set into relation with the repertoire size. Statistical analyses selected the categories that were significantly overrepresented in the CIDP repertoire compared with the HC repertoire.