CMV-Cre mice (Jackson lab, stock#: 006054) (ref. [15]), FSF-R26CAG − CreERT2/+ mice (ref. [17]), the human beta-actin FLPe deleter strain of mice (B6;SJL-Tg (ACTFLPe)9205Dym/J, the Jackson Laboratory, Stock Number: 003800) and R26CAG − CreERT2/+ mice [24] have been described previously [20]. The mice were all on a mixed C57Bl/6;129S6/SvEv genetic background. All mice were kept at a SPF environment, no mice were excluded from analyses. Experiments with mice were performed with protocols approved by the Shandong University Institutional Animal Care and Use Committee, complying with the rules of Regulations for the Administration of Affairs Concerning Experimental Animals (Approved by the State Council of China). Mice after the study were all euthanized by cervical dislocation.
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